Date of Award

December 2020

Document Type

Dissertation

Degree Name

Doctor of Philosophy (PhD)

Department

Healthcare Genetics

Committee Member

Tracy Fasolino

Committee Member

Mary Beth Steck

Committee Member

Joseph Bible

Committee Member

Joel Williams

Abstract

The first chapter in this manuscript serves as an overview of the background, significance, and theological framework of this study, comparison of papillary renal cell carcinoma type 1 and type 2: a secondary analysis. The body of this work focuses on the topics of the current knowledge, genetic variations and syndromes, demographics, increased risk factors, and pathways associated with type 1 and type 2 papillary renal cell carcinoma.

The second chapter is a review of the literature to discuss the current working knowledge on papillary renal cell carcinoma including genetic underpinnings, disease management and histological subtyping. This chapter was designed to give clinicians a better working knowledge on papillary renal cell carcinoma. The results of this review highlight the importance of discovering discernible differences between type 1 and type 2 papillary renal cell carcinoma tumors.

The third chapter is a review of the most common hereditary renal cell syndromes that are associated with an increased risk of developing renal cell carcinomas. This review covered Hereditary Leiomyomatosis and Renal Cell Cancer, a renal cancer syndrome that is characterized by benign neoplasms and is associated with an increased risk of developing type 2 papillary renal cell carcinoma. The results of this review highlighted the complex genetic nature of papillary renal cell carcinoma and provided the background for a variable used in the secondary data analysis.

The fourth chapter describes the dissertation work and was a secondary data analysis on papillary renal cell carcinoma using The Cancer Genome Atlas – Cervical Kidney Renal Papillary Cell Carcinoma and cBioPortal databases. The analysis focused on determining the epidemiological, increased risk factor and pathway preference differences between type 1 and type 2 papillary renal cell carcinoma. The results of this study showed that while there are some significant differences between tumor types, further studies are warranted.

The final chapter is a synthesis of all the manuscripts related to papillary renal cell carcinoma type 1 and type 2 tumors. This chapter provides a cohesive discussion of all three manuscripts and provides suggestions for future research specific to type 1 and type 2 papillary renal cell carcinoma. The result of all three manuscripts is to better provide an understanding of papillary renal cell carcinoma as a disease and to define differences between type 1 and type.

Share

COinS
 
 

To view the content in your browser, please download Adobe Reader or, alternately,
you may Download the file to your hard drive.

NOTE: The latest versions of Adobe Reader do not support viewing PDF files within Firefox on Mac OS and if you are using a modern (Intel) Mac, there is no official plugin for viewing PDF files within the browser window.