Title
Data from: Genetic analyses in Lake Malawi cichlids identify new roles for Fgf signaling in scale shape variation
Description
Elasmoid scales are the most common epithelial appendage among vertebrates, however an understanding of the genetic mechanisms that underlie variation in scale shape is lacking. Using an F2 mapping cross between morphologically distinct cichlid species, we identified >40 QTL for scale shape at different body positions. We show that while certain regions of the genome regulate variation in multiple scales, most are specific to scales at distinct positions. This suggests a degree of regional modularity in scale development. We also identified a single QTL for variation in scale shape disparity across the body. Finally, we screened a QTL hotspot for candidate loci, and identified the Fgf receptor fgfr1b as a prime target. Quantitative rtPCR and small molecule manipulation support a role for Fgf signaling in shaping cichlid scales. While Fgfs have previously been implicated in scale loss, these data reveal new roles for the pathway in scale shape variation.
Publication Date
10-17-2019
Publisher
Zenodo
DOI
10.5061/dryad.35cp405
Document Type
Data Set
Recommended Citation
Albertson, R. Craig; Kawasaki, Kenta C.; Tetrault, Emily R.; Powder, Kara E. (2019), "Data from: Genetic analyses in Lake Malawi cichlids identify new roles for Fgf signaling in scale shape variation", Zenodo, doi: 10.5061/dryad.35cp405
https://doi.org/10.5061/dryad.35cp405
Identifier
4950635
Embargo Date
10-17-2019
Version
1