Our Creative Inquiry team is researching the anti-tumor potential of compounds isolated from Physalis peruviana (poha) fruit. CellTiter 96 Aqueous Non-radiative Cell Proliferation Assays (Promega, 2012) were performed to screen the inhibitory activity of the compounds on human lung carcinoma A549 cells and breast cancer MDA-MB- 231 cells with the corresponding non-tumorigenic epithelial cell line NL20 and MCF-10A as controls. The cells were treated with compounds at concentrations of 0μg/ml, 2μg/ml, 5μg/ml, and 20μg/ml and incubated for 24, 48, and 72 hours.
Huggins, Haley; Brierley, Stephanie; Shearer, Alyssa; Burns, Alicia; Yang, Iris; Tietje, Ashlee; and Wei, Yanzhang, "Identification and Functional Evaluation of Anti-Cancer Ilmmunomodulators from Physalis peruviana (Poha)" (2015). Focus on Creative Inquiry. 130.