Date of Award

12-2006

Document Type

Thesis

Degree Name

Master of Science (MS)

Legacy Department

Bioengineering

Advisor

Burg, Karen J.L.

Abstract

The purpose of this study was to develop and assess a potential key feature in a minimally-invasive breast reconstruction device and to collect information for an in vitro tissue test system. Tannic acid is a hydrolysable plant tannin, and it has been determined that tannic acid functions as a collagen crosslinking agent through both hydrogen bonding mechanisms and hydrophobic effects. Additionally, current research suggests that tannic acid may have anti-tumor properties. Therefore, it has been proposed that tannic acid can be used as an agent to induce apoptotic processes in any transplanted adult stem cells that are inclined to spontaneously transform. Furthermore, collagen scaffolds can be used as a vehicle to deliver tannic acid to the tissue margins surrounding a tumor following a lumpectomy procedure as a form of adjuvant therapy.

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