Document Type
Patent
Publication Date
9-10-2013
Patent Number
patent number 8529951
Abstract
Disclosed are elastogenic cues that can be utilized to encourage growth and development of elastin-containing cellular constructs. The elastogenic cues include hyaluronan fragments and oligomers, optionally in conjunction with growth factors and/or a source of copper ions. The elastogenic cues can up-regulate elastin matrix synthesis and by vascular smooth muscle cells. In addition to encouraging synthesis of elastin in a cellular matrix and organization into elastic fibers, the elastogenic cues can also stabilize the formed ECM matrix through suppression of elastin-laminin receptor (ELR). In addition, the elastogenic cues can inhibit cell hyper-proliferation (e.g., hyperplasia) common in inflammatory vascular disease.
Application Number
12/034237
Filing Date
2008-02-20
Primary/U.S. Class
424/488
Other/U.S. Class
424/461, 424/493, 514/7.6, 514/54, 514/499