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Prescription drugs and marijuana have been used and abused across college campuses for many years, but recent data show that usage has been increasing. This goal of this research project has been to understand the perceptions of prescription drugs and marijuana among users within a college setting, and compare the results with a similar study conducted at Duke and UNC Greensboro. A quarter of the Clemson University undergraduate student population was administered a survey, with 9% response rate. Respondents included a range of diverse ethnic origins, genders, class standings, and fields of study. The questions specifically focused on student opinions, perceptions, and behaviors concerning the illegal use of marijuana and abuse of prescription drugs. Nearly 40% of students surveyed indicated that use of marijuana and abuse of prescription drugs are major issues facing students at Clemson. Approximately 11% of respondents have been diagnosed with attention deficit/hyperactivity disorder (ADHD) and have prescriptions for ADHD medications. Data matched very closely with results of studies at other institutions, indicating that Clemson students share the same perceptions and potential for prescription abuse as students at other institutions. Results will be used for further research and implementation of action to provide educational resources to Clemson students.