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Theses from 2022

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Single Asperity Fretting Corrosion of Traditional and Additively Manufactured Metallic Biomaterials: Quantitative Analysis from Acetabular Tapers to Micron and Nanometer Scale Tribocorrosion, Annsley Mace

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Nonviral Approaches for Delivery of CRISPR-Cas9 Into Hepatocytes for Treatment of Inherited Metabolic Disease, Tanner R. Rathbone

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Development and Application of 3D Kinematic Methodologies for Biomechanical Modelling in Adaptive Sports and Rehabilitation, Anne Marie Severyn

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Systems Modeling of Collagenous Tissue Degradation: Protease and Mechanical Interactions, Amirreza Yeganegi

Theses from 2021

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The in Vivo and in Vitro Characterization of Collagen/Tannic Acid Beads as an Injectable Tissue Regenerative Scaffold for Breast Reconstruction Post-Lumpectomy, Andrew Baldwin

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Development of a Tissue Engineered Pulmonary Heart Valve for Pediatric Patients, Maria Margarita Rodriguez Bruce

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Development of a Hybrid Hydrogel Drug Delivery System for Treatment of Ischemic Injury, Andrew DeMaria

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Influencing the Inflammatory Response Through Multi-Scale Geometry, Antibiotic Release, and Fluid Management in a Textile-Based Biomaterial Wound Dressing, Elizabeth Gianino

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Development of Solution Blow Spun Nanofibers as Electrical and Whole Cell Biosensing Interfaces, Craig Levar Miller

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Systems Modeling to Predict Mechano-Chemo Interactions In Cardiac Fibrosis, Jesse Daniel Rogers

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Novel Peptide Biomaterials for Enhanced Delivery of siRNA Cargo for Treatment of Ovarian Cancer, Timothy Samec

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Development of Tissue Engineered Scaffolds for Cardiovascular Repair and Replacement in Pediatric Patients, Dipasha Sinha

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Time-Lapse Observation of Sarcomeric Addition in Hypertrophic Models Based on a Tissue Like Cardiomyocyte Culture, Ailin Wei

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The Fundamentals of Fretting Crevice Corrosion of Metallic Biomaterials for Orthopedic Implants, Dongkai Zhu

Theses from 2020

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Using Heparin-Coated Nanoparticles in the Treatment of Neointimal Hyperplasia, Nardine M. Ghobrial

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Experimental Characterization and Biological Assessments of Polymeric Mesh Implants, Xinyue Lu

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Understanding Corrosion in Modular Acetabular Tapers: Retrieval Analysis, In Vitro Testing and Cell-Material Interactions, Aarti Shenoy

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Development of Extracellular Vesicle Isolation and Model Systems Toward Early Ovarian Cancer Diagnostics, Tyler Slonecki

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Compliance, Hardness, and Fretting Corrosion in Modular Taper Junctions: The Micromechanics of Contact, Stephanie Marie Smith

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Diagnosis, Rupture Risk Evaluation and Therapeutic Intervention of Abdominal Aortic Aneurysms Using Targeted Nanoparticles, Xiaoying Wang

Theses from 2019

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The Mechanical and Functional Effects of Ionizing Radiation on Articular Cartilage, Hannah Cash

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The Role of Tbx5 in Sinoatrial Node Differentiation in Mouse Embryonic Stem Cell Derived Cardiomyocytes, Yunkai Dai

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Development of Tissue Engineered Vascular Grafts Resistant to Diabetes Mellitus, Jhilmil Dhulekar

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Targeted EDTA Chelation Therapy with Albumin Nanoparticles to Reverse Arterial Calcification and Restore Vascular Health in Chronic Kidney Disease, Saketh Ram Karamched

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Electrochemical Assessment of Alumina-TiC Composite: A Potential Biomaterial, Hetal Umesh Maharaja

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Understanding the Warburg Phenotype and the Metabolic Plasticity of Proliferative Mammalian Cells Using 13C Metabolic Flux Analysis, Daniel Odenwelder

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Development of a Nucleus Pulposus Implant for Intervertebral Disc Repair, Joshua Dillon Walters

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Inflammation and Corrosion in Total Hip Prostheses: The Generation and Interaction of Reactive Oxygen Species with CoCrMo Metallic Biomaterial Surfaces, Michael John Wiegand

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Polarization-Resolved Second Harmonic Generation Microscopy Study of Cardiac Hypertrophy, Cai Yuan

Theses from 2018

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Development of a Biomimetic, Collagen-Based Scaffold for the Repair and Regeneration of the Annulus Fibrosus, Ryan Borem

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Engineering Soft Tissue Replacements and the Development of Novel Technologies to Heal these Wounds, Sarah Grace Dennis

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Chemically Active Rheological Modifiers for the Improved Clinical Use of Cyanoacrylates, Kyle Joseph Garcia

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Computational Approaches to Understanding Structure-Function Relationships at the Intersection of Cellular Organization, Mechanics, and Electrophysiology, Tyler George Harvey

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Surface Modification of Orthopaedic Fracture Fixation Implants for Infection Prevention and Improved Limb Salvage Outcomes, Sarah Helms

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Simulated Inflammation by Hypochlorous Acid and the Corrosion and Tribocorrosion of Orthopedic Alloys: Feedback Between Corrosion and Inflammation, Gregory Walter Kubacki

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Tissue Engineering Platforms for Cardiac Pathology in Diabetes: In Vitro and In Vivo Studies, Laura Elizabeth McCallum

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Targeted Delivery of Drug Loaded Albumin Nanoparticles to Emphysematous Lungs to Preserve Elastin and Mitigate Matrix Metalloproteinase Activity, Vaideesh Parasaram

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Development of Biomimetic Models of Human Cardiac Tissue, Dylan Jack Richards

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Computational Modeling of Nonlinear Behavior in Orthopaedics, Kyle Snethen

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Behavioral, Functional, and Shape Assessment for Temporomandibular Joint, Feng Wei

Theses from 2017

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Antifibrotic Effects of Vibratory Stimulation, Sooneon Bae

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Whole Body Irradiation and Degradation of Structural and Functional Properties of Mouse Bone: X-rays, Protons, and Heavy Ions, Laura Christine Bowman

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In Vitro Diabetic-Hypertensive Cellular-Response Evaluation Model for In-Stent Restenosis, Varun Chawla

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Development of a Tissue Engineered Mitral Valve, Christopher Patrick deBorde

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Naturally Derived Anti-Inflammatory and Antibacterial Coatings for Surgical Implants, Dmitry Gil

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Target-Specific Capture of Relevant Gaseous Compounds Using Natural and Synthetic Nano and Micro Materials, Fernanda Delbuque Guerra

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Fabrication of Human Serum Albumin Film for Enhanced Hemocompatibility and Mitigation of Intimal Hyperplasia Under Physiologically Relevant Flow Shear Conditions, Astha Khanna

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Flow Assessment Using Optical Coherence Microscopy Based Particle Image Velocimetry, Siyu Ma

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Towards Computer Aided Management of Kidney Disease, Vipul Pai Raikar

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Towards Real-time Remote Processing of Laparoscopic Video, Zahra Ronaghi

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Nanowired Human Cardiac Spheroids for Cardiac Regenerative Medicine, Yu Tan

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Multifunctional Polymeric Micelles for Drug Resistant Breast Cancer: Self-Assembling Poly(Lactide-Co-Glycolide)-Graft-Polyethylenimine, Graham MacKenzie Temples

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Real-time Observation of Dynamic Sarcomeric Addition in an In Vivo-like Cardiomyocyte Culture Model, Zhonghai Wang

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An Integrative Approach to Elucidating the Governing Mechanisms of Particles Movement under Dielectrophoretic and Other Electrokinetic Phenomena, Yu Zhao

Theses from 2016

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Computational Studies of Molecular Mechanisms Mediating Protein Adsorption on Material Surfaces, Tigran M. Abramyan

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Nutrient Related Mechanisms of Intervertebral Disc Degeneration, Sarah Elizabeth Cisewski

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Creation of a Pioneer-Neuron Axonal Pathfinding Model for Future Applications in Developmental Neurotoxicity Testing, Nicholas Robert Erdman

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Understanding the Transcriptional Landscape of Chinese Hamster Ovary (CHO) Cell Lines Using Next-Generation Sequencing Technology, RNA-seq, under Industrially Relevant Conditions, Yogender Kumar Gowtham

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Targeted Nano-Therapeutices for the Reversal of Calcification and ECM Degradation in Abdominal Aortic Aneurysms, Nasim Nosoudi

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Impact of Ionizing Radiation Dose and Dose Rate on Adipose Stem Cell Function, Matthew Connor Rusin

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Novel Chemical Crosslinking to Stabilize Extracellular Matrix for Bioprosthetic Heart Valve Materials to Resist Calcification and Structural Degradation, Hobey Tam

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Comprehensive Investigation into the Utility of Amnion Membrane Derived Stem Cells for Orthopedic Regenerative Medicine Applications, Natasha Topoluk

Theses from 2015

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Manipulation of the Electrical Double Layer for Control and Sensing in a Solid State Nanopore, Samuel L. Bearden

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Investigating into the Dynamics of Mammalian Cell Growth: Using In Vitro to Help Improve Therapies, Arthur Nathan Brodsky

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Design and Development of a Selectively Absorbable Multiphasic Hernia Mesh an In Vivo Performance as it Relates to Biocompatibility, Georgios T. Hilas

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Trilayer Tissue Engineered Heart Valves for Aortic Valve Replacement, Michael Paul Jaeggli

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Carbon Nanotube-Enzyme Conjugates for the Fabrication of Diagnostic Biosensors, Olukayode Adedamola Karunwi

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Hybrid Hydrogels for Tissue Engineering, Ho Joon Lee

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Understanding the Fusion and Maturation of Tissue Engineered Linear Blood Vessels Using Magnetic Cellular Spheroids, Timothy R. Olsen

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Development and Validation of a Novel In Vitro Model for the Assessment of Heterocellular Interactions Mediated by Connexin43, Emily Ongstad

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Mechanically- and Electrochemically- Induced Damage at Metal Interfaces of Joint Replacements and the Biological Consequences, Pooja Panigrahi

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CONTRA-COMPARTMENTAL JOINT MECHANICS IN UNICONDYLAR KNEE ARTHROPLASTY, Roy Rusly

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CAPILLARY CHANNEL POLYMER FIBER-BASED SCAFFOLDS FOR NEURAL REGENERATION, Atanu Sen

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Investigating Polymer based Scaffolds for Urinary Bladder Tissue Engineering, Srikanth Sivaraman

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Development and Fabrication of Novel Woven Meshes as Bone Graft Substitutes for Critical Sized Defects, Jordan Anthony Stowe Gilmore

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DEVELOPMENT, VALIDATION, AND APPLICATION OF ANALYTICAL METHODS FOR CHARACTERIZING ADSORBED PROTEIN ORIENTATION, CONFORMATION, AND BIOACTIVITY, Aby Thyparambil

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EFFECTS OF GROWTH FACTOR SUPPLEMENTATION AND ENVIRONMENTAL CONDITIONS ON HUMAN ADIPOSE-DERIVED STEM CELL DIFFERENTIATION TOWARDS UROTHELIAL LINEAGE, James Turner

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Biomechanical Characterization and Modeling of Human TMJ Disc, Gregory Wright

Theses from 2014

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Investigating the Effects of Biochemical and Biophysical Signals on Vascular Smooth Muscle Cell Differentiation, Ruikai Chen

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Cardiovascular Tissue Engineered Constructs for Patients With Diabetes, James Chow

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MONTE CARLO MODELING BASED PATIENT DOSE OPTIMIZATION IN DIAGNOSTIC RADIOLOGY, Wenjun He

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The Development and Characterization of Tannic Acid Cross-linked Collagen Scaffolds for the Prevention of Breast Cancer Recurrence in Lumpectomy Patients, Beau Inskeep

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MECHANISMS AND REVERSAL OF ELASTIN SPECIFIC MEDIAL ARTERIAL CALCIFICATION, Yang Lei

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Clinical, Kinematic, and Kinetic Analysis of Knee Arthrodesis in Support of the Design of a Novel Treatment Alternative, Eric Montgomery Lucas

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Development of an In Vitro Three-dimensional Breast Tissue Model to Decipher the Effects of Stromal Heterogeneity on Normal and Cancerous Mammary Epithelial Cells, Erin McCave

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The Effects of Applied Hydrostatic Pressure on Osteogenic Differentiation of Mouse Mesenchymal Stem Cells in an In Vitro 3D Culture, Brittany McGowan

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Towards Image-Guided Pediatric Atrial Septal Defect Repair, Fuad Mefleh

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The Potential of Exogenous Fatty Acids in Breast Tissue Engineering, Richard Thomas Pace

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Influence of Periostin on Bone Marrow-Derived Cell Contribution to Dermal Wound Repair, Suzanne Parks

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DEVELOPMENT OF A TRANSLATIONAL, TISSUE-ENGINEERED APPROACH TO REPLACEMENT OF MYOCARDIAL INFARCT SCAR TISSUE, Jason Schulte

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Platform Technologies to Advance Clinically Relevant Tissue Engineered Heart Valve Products, Leslie Neil Sierad

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Development of a Transport System for Advancing Tissue Engineering and Cell Identification, Suzanne Mae Tabbaa

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TARGETED DELIVERY OF ANTI-INFLAMMATORY AND ANTI-OXIDANT DRUGS FOR TREATMENT OF CHRONIC OBSTRUCTIVE PULMONARY DISEASES, Yun Xiang

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Effect of Patellar Component Thickness on Patellar Kinematics and Patellofemoral Joint Function Following Total Knee Replacement, Xin Xie

Theses from 2013

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SUSTAINED RELEASE OF ESTROGENS FROM PEGYLATED NANOPARTICLES FOR TREATMENT OF SECONDARY SPINAL CORD INJURY, John Barry

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Ion Channel-mediated Hydrostatic Pressure Mechanotransduction in Urothelial Cells, Kevin Champaigne

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BIOLOGICAL SCAFFOLDS FOR PERIPHERAL VASCULAR SURGERY, George Fercana

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Engineering a Biomimetic Structure for Human Long Bone Regeneration, Eleni Katsanevakis

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IMPLANTABLE BIOSENSORS FOR PHYSIOLOGIC STATUS MONITORING DURING HEMORRHAGE, Christian Kotanen

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Engineering Beta-Cell Spheroids for Type 1 Diabetes Treatment, Xiaoyan Liu