patent number 5011494
A soft tissue implant device such as a catheter, heart valve, or plastic or reconstructive surgical material, to be at least partially embedded in an implantation site in soft organic tissue of a living organism includes a body defining a surface layer extending over the portion of the body contacting the organic tissue. The surface layer defines a three-dimensional pattern with an exterior surface defining a plurality of spaces and a plurality of solid surface portions. The spaces have a mean bridging distance ranging from greater than 1.0 micron to less than 4.0 microns and the solid surfaces portions have mean breadths ranging from 0.10 micron to 2.0 microns. The mean bridging distance is preferably greater than 1.4 microns and less than 1.9 microns. The exterior surface is substantially free of indentations having a bridging distance measuring in a range from between 10.0 microns and 1,000 microns.
Clemson University (Clemson, SC)