It is well known that fluorinated molecules play an important role in daily life. For example, organic molecules bearing either a fluorine atom itself or a short polyfluorinated substituent such as mono-, difluoro-, and trifluoromethyl groups, or pentafluoroethyl and perfluoropropyl groups are already widely used in medicinal and agricultural chemistry. In contrast, molecules with long perfluorinated chains have found vast application in materials science. Among the fluorine-containing moieties, the pentafluorosulfanyl (SF5) substituent occupies a special place.1 The pentafluorosulfanyl group brings unique properties to organic compounds and often improves their biological activities due to the group’s high chemical and metabolic stability, significant lipophilicity, substantial steric effect, unique geometry, and low surface energy. Here we present new routes towards SF5-substituted aliphatic and heterocyclic compounds.
Matsnev, Andrej V.; Belina, Steven P.; Qing, Si-Yan; Berger, Kyle A.; Scavuzzo, Anthony R.; Dudzinski, Piotr; Dreier, Anna-Lena; Haufe, Günter; and Thrasher, Joseph S., "Recent Advances in the Synthesis and Application of SF5-Containing Organic Compounds" (2016). Chemistry Annual Research Symposium. 3.