Title

Multimolecular characteristics of cell-death related hub genes in human cancers: a comprehensive pan-cancer analysis

Creators

Xiaoshuang Ren, Department of Social Management, Ritsumeikan University
Ziye Yan, Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University
Xiaoqi Lou, Department of Oncology, The First Affiliated Hospital of Anhui Medical University
Fang Wang, Department of Oncology, The First Affiliated Hospital of Anhui Medical University
Ying Teng, Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University
Yanfeng Zou, Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University
Yu Lei, Department of Oncology, The First Affiliated Hospital of Anhui Medical University
Dingtao Hu, Clinical Cancer Institute, Center for Translational Medicine, Second Military Medical University
Nana Meng, Department of Quality Management Office, The Second Affiliated Hospital of Anhui Medical University
Tingyu Zhang, Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University
Bizhi Tu, Department of Orthopedics, The First Affiliated Hospital of Anhui Medical University
Zhen Li, Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University
Linlin Wang, Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University
Yuhua Wang, Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University

Description

Failure of the normal process of cell death pathways contributes to the defection of immune systems and the occurrence of cancers. The key genes, the multimolecular mechanisms, and the immune functions of these genes in pan-cancers remain unclear. Using online databases of The Cancer Genome Atlas, GEPIA2, TISIDB, HPA, Kaplan-Meier Plotter, PrognoScan, cBioPortal, GSCALite, TIMER, and Sangerbox, we identified the key genes from the six primary cell death-related pathways and performed a comprehensive analysis to investigate the multimolecular characteristics and immunological functions of the hub genes in 33 human cancers. We identified five hub genes in the six primary cell death-related pathways (JUN, NFKB1, CASP3, PARP1, and TP53). We found that CASP3, PARP1, and TP53 were overexpressed in 28, 23, and 27 cancers. The expression of the five genes was associated with the development and prognosis of many cancers. Particularly, JUN, NFKB1, CASP3, and TP53 have prognostic values in Brain Lower Grade Glioma (LGG), while PARP1 and CASP3 could predict the survival outcomes in Adrenocortical carcinoma (ACC). In addition, an extensive association between five genes’ expression, DNA methylation, and tumor-immune system interactions was noticed. The five cell death-related hub genes could function as potential biomarkers for various cancers, particularly LGG and ACC. The immunological function analysis of the five genes also proposes new targets for developing immunosuppressants and improving the immunotherapy efficacy of cancers. However, further extensive clinical and experimental research are required to validate their clinical values.

Publication Date

1-1-2022

Publisher

figshare Academic Research System

DOI

10.6084/m9.figshare.20332150

Document Type

Data Set

Recommended Citation

Ren, Xiaoshuang; Yan, Ziye; Lou, Xiaoqi; Wang, Fang; Teng, Ying; Zou, Yanfeng; Lei, Yu; Hu, Dingtao; Meng, Nana; Zhang, Tingyu; Tu, Bizhi; Li, Zhen; Wang, Linlin; Wang, Yuhua (2022), "Multimolecular characteristics of cell-death related hub genes in human cancers: a comprehensive pan-cancer analysis", figshare Academic Research System, doi: 10.6084/m9.figshare.20332150

https://doi.org/10.6084/m9.figshare.20332150

Identifier

10.6084/m9.figshare.20332150

Related Content

10.1080/15384101.2022.2101337

Embargo Date

1-1-2022