Document Type
Patent
Publication Date
11-23-2010
Patent Number
patent number 7838000
Abstract
Disclosed are treatment agents and methods of treatment utilizing the agents directed toward diseases in which the disease causing pathogen includes .alpha.6.beta.1 integrin receptors and/or .alpha.6.beta.4 integrin receptors on the surface of the pathogen. In one embodiment, the disease can be breast cancer. The therapeutic agents disclosed include a polypeptide comprising at least a portion of the G domain of the laminin-5 .alpha.3 chain that has been shown to bind .alpha.6.beta.1 integrin receptors and .alpha.6.beta.4 integrin receptors. In one embodiment, the therapeutic agents can be fused or chimeric materials in which the laminin-5 .alpha.3 chain polypeptide has been chemically bound to another material that can be useful in the destruction or neutralization of the pathogen.
Application Number
11/440746
Assignees
Clemson University Research Foundation (Clemson, SC, US)
Filing Date
2006-05-25
Primary/U.S. Class
424/184.1
Other/U.S. Class
514/19.4