Structurally similar polyphenols have opposite effects on rates of Fe3+ reduction by NADH. In future work, we anticipate exploring several avenues:
What is the role of autoxidation? UV-vis kinetic experiments in an air-free atmosphere should reveal if MEGA is increasing the pool of reducible Fe3+.
What occurs in the presence of H2O2 and/or increased levels of NADH? Mimicking the environment of a stressed cell should yield interesting information about antioxidant activity if the rates change significantly.
Goodman, Craig and Brumaghim, Julia L., "Understanding the Role of NADH in Cellular Fe2+ Generation of Hydroxyl Radical and the Effects of Polyphenol Antioxidants" (2016). Chemistry Annual Research Symposium. Paper 8.