Date of Award

5-2016

Document Type

Thesis

Degree Name

Master of Science (MS)

Legacy Department

Bioengineering

Committee Member

Dr. Delphine Dean, Committee Chair

Committee Member

Dr. Martine LaBerge

Committee Member

Dr. O. Thompson Mefford

Abstract

With the ever-increasing prevalence of atherosclerosis, procedures such as angioplasty and stenting have become common practice, both of which are simple techniques spouting relatively satisfying results for the past several decades. While successful in opening of occluded vessels, these therapies can be met down the line with thrombosis or even repeated occlusion of the vessel, known as restenosis. Similar to the issues faced within oncology, treatment of this restenosis via widespread drug administration throughout the body is not desirable. Cardiovascular and other medical fields have begun looking into the use of magnetic nanoparticles as a drug delivery vessel. Previously, our lab proposed the use of these particles to concentrate and carry drug doses for local delivery as treatment of neointimal hyperplasia leading to restenosis. This pairing would allow concentrated drug doses to be carried directly to the affected vessel position, without adverse effects elsewhere in the vessel or even the entire body.

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